use wxWidgets (wxPython)

• native look and feel
• mature API
• IDE: see http://wiki.wxwidgets.org/Tools

docs:

• wxPython tutorial
• wxPython Style Guide
• Getting started with wxPython
• wxPython video tuturials

installing wxPython on ubuntu:

sudo aptitude install python-wxgtk2.8

alternatives:

FLTK

• non-native look and feel
• more lightweight, smaller libraries
• smaller learning curve

GTK

• non-native look and feel
• primary framework for Gnome
• IDE: Glade

Qt

• native framework for KDE
• not quite native for Gnome
• license fees for commercial apps
• IDE: Qt Designer